SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease

ACE2+ gene expression signatures in diabetic kidney disease (DKD) and COVID-19 patients in proximal tubule cells (PTEC)
[Published in Kidney International]


DKD ACE2+ expression signature (3000 genes)

The 9 functional modules characterizing the genes upregulated in ACE2+ cells in DKD (ACE2+ vs ACE2- in DKD)


DKD-induced ACE2+ expression signature (839 genes)

The 9 functional modules characterizing the genes upregulated in DKD ACE2+ cells (DKD ACE2+ vs living donor ACE2+)


COVID ACE2+ expression signature (2896 genes)

The 10 functional modules characterizing the genes upregulated in ACE2+ cells from the PTEC in urine of COVID patients (ACE2+ vs ACE2- in urine sample PTEC)


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