SARS-CoV-2 receptor networks in diabetic kidney disease, BK-Virus nephropathy and COVID-19 associated acute kidney injury

ACE2+ gene expression signatures in DKD, BK virus, and COVID-19 associated AKI in proximal tubule cells
[medRxiv preprint]

Overlapping ACE2+ expression signature (1047 genes)


The 10 functional modules characterizing the disease ACE+ expression signature (DKD and BK virus)


SARS-CoV-2 overlap ACE2+ expression signature (333 genes)

The 9 functional modules characterizing the genes in our overlapping ACE2+ expression signature that are also known to respond to SARS-CoV-2 infection (Bojkova 2020)

COVID-19 associated acute kidney injury ACE2+ expression signature (295 genes)

The 4 functional modules characterizing the ACE2+ expression signature from PT cells derived from the urine of a SARS-CoV-2 infected patient


Diabetic kidney disease ACE2+ expression signature (1475 genes)

The 13 functional modules characterizing the DKD ACE2+ expression signature

BK virus-infected ACE2+ expression signature (2107 genes)

The 14 functional modules characterizing the BK virus-infected ACE2+ expression signature

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